New microscopy technology helps scientists peer deeper into brain
May 27 (UPI) — Scientists have managed to extend the depth at which microscopic fluorescence imaging can penetrate and map the interior structures of the brain.
Fluorescence microscopy has previously been used on animal models to yield high-resolution brain images, revealing impressive molecular and cellular details at shallow depths. But the process is quite invasive and limited in scope.
Because light beams are quickly scattered by the skin and skull, fluorescence microscopy is limited in its ability to penetrate and image the brain’s interior.
But not all light is equally susceptible to scattering.
To extend the depth of microscopic fluorescence imaging, scientists in Switzerland utilized a distinct spectral window called second near-infrared, which encompasses light wave frequencies ranging from 1,000 to 1,700 nanometers. The use of second near-infrared light, which is…